Small-Molecule Drug Discovery

We work with clients to move their discovery projects forward to key milestones or value inflection points. This includes:

  • Identifying new hit and lead molecules for early-stage projects
  • Optimising lead series and delivering preclinical candidate molecules
  • Tailoring the approach towards oral, intravenous or inhaled administration and optimising for CNS penetration or exclusion
Our Approaches
  • Apply cutting-edge virtual screening and file-mining approaches to identify novel hits with optimal physicochemical properties
  • Use our knowledge of structural alerts and toxicophores to minimise risks of structure-related compound attrition
  • Develop lead series with defined SAR and early assessment of key risks
  • Optimise templates to deliver high quality preclinical candidates