| Home |
About |
Network |
Expert Design Support
Drawing on our experience of leading and managing multi-disciplinary drug discovery project teams, we can work with clients to:
- Optimise screening sequences to ensure they are fit for purpose and can enable delivery of high-quality candidate molecules
- Apply cutting-edge techniques such as chemical proteomics and design of activity-based probes to understand the biology of a given target or molecule
- Apply
virtual screening and file-mining approaches to
identify novel hit matter
- Analyse
output from high-throughput screens, triaging clusters
of hits and identifying promising starting points
using parameters such as ligand efficiency, lipophilic
efficiency, ADME properties, off-target activity,
binding mode, scope for modification and IP analysis
- Follow up
screening hits rapidly to generate lead series with
demonstrable structure-activity relationships; develop
an understanding of the risks that each template
presents to allow efficient decision making in terms
of series progression or termination
- Optimise lead
series using an holistic approach to deliver
preclinical candidates that meet required biological,
ADME, Pharm Sci and drug-safety properties
- Designing molecules to cross the blood-brain barrier whilst retaining drug-like properties
- Designing molecules to be peripherally restricted whilst retaining oral absorption
- Identifying and designing kinase inhibitors with slow binding kinetics
- Designing molecules that can be delivered by inhaled or topical routes that show a long duration of action and high therapeutic index
- Enzymes (including phosphodiesterases, metalloproteinases, kinases, histone demethylases and acetylases)
- GPCRs
(aminergic, peptidergic, class B); agonists, partial
agonists, antagonists, inverse agonists, orthosteric
and allosteric binders
- Nuclear hormone receptors
- Ligand- and voltage-gated ion channels
- Monoamine transporters
- Protein-protein
interactions
- Allergy and
Respiratory
- Anti-viral
and Anti-fungal Diseases
- CNS Disorders
- Gastrointestinal
- Genitourinary
- Parasitic
Diseases
- Obesity
- Oncology
- Pain
- Regenerative
Medicine
- Tissue
Repair
